Dokumentumok
Clinical course of laryngo-respiratory symptoms in gastro-oesophageal reflux disease during routine
BACKGROUND: Gastro-oesophageal reflux disease (GERD) can be associated with laryngo-respiratory symptoms (LRS) such as chronic cough, asthma or laryngeal symptoms. AIM: To analyse the long-term clinical course of LRS in a large population with GERD and LRS. Methods ProGERD is a prospective multicentre cohort study of 6215 adult out-patients with GERD. At baseline, the prevalence of LRS was assessed. Initial standardized treatment was esomeprazole for up to 8 weeks. After 5 years of follow-up, patients were interviewed for LRS and a multivariate analysis was performed with resolved vs. persistent symptoms for chronic cough, asthma and laryngeal symptoms. RESULTS: In all, 2886 patients (46.4%) were available for analysis at baseline and at 5 years. The prevalence of chronic cough and laryngeal disorders had decreased while the prevalence of asthma had increased. Resolution of LRS was independent of clinical reflux characteristics or PPI medication. CONCLUSIONS: In a large population with GERD, only few patients reported persistent LRS over 5 years. Resolution of LRS was independent of the stage of GERD and PPI treatment. Accordingly, data on the direction of causality between GERD and LRS are lacking and the strength of the association between the two must remain controversial. Aliment Pharmacol Ther. 2009 Jun 1; 29(11):1172-8. More»
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Exposure to Low-Dose Ionizing Radiation from Medical Imaging Procedures
Background: The growing use of imaging procedures in the United States has raised concerns about exposure to low-dose ionizing radiation in the general population. Methods: We identified 952,420 nonelderly adults (between 18 and 64 More»
Use and impact of early endoscopy in elderly patients with peptic ulcer hemorrhage: a population-bas
Background: Upper endoscopy performed within 1 day of presentation, or early endoscopy, has been proposed as an intervention to improve the efficiency and outcomes of care for patients with peptic ulcer hemorrhage. However, the More»
Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
Chronic infection with hepatitis C virus (HCV) affects 170 million people worldwide and is the leading cause of cirrhosis in North America. Although the recommended treatment for chronic infection involves a 48-week course of peginterferon--2b More»
Detecting malignant lesions by endoscopy in 2741 primary care dyspeptic patients w/o alarm symptoms
BACKGROUND & AIMS: Current guidelines recommend empirical, noninvasive approaches to manage dyspeptic patients without alarm symptoms, but concerns about missed lesions persist; the cost savings afforded by noninvasive approaches More»
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Gyulladásos bélbetegségek Szia,Kedvesek a metaforáid,
2010, Február 25. 23:20 Csizkat
Gyulladásos bélbetegségek Részemről eddig OK :)Nem
2010, Február 25. 14:43 chysh
Gyulladásos bélbetegségek Maga a Crohn kialakulasa
2010, Február 25. 11:53 Richard
