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100% at the KRAS European External Quality Assessment Schemes 2010
As the only Hungarian diagnostic service provider KPS Molecular Diagnostics scored 100% at KRAS European External Quality Assessment Schemes 2010 organized by the European Society of Pathologists. Samples for the KRAS European external quality assessment scheme 2010 were dispatched in July 2010. Each participant received 3 unstained sections, paraffin-embedded material from 10 invasive colorectal carcinomas to be analysed for the presence of KRAS mutations. More»
KPS is on the genomic map of the world
KPS Molecular Diagnostics has been chosen as a key genomic infrastructure provider in the Central-European Region. The University of Birmingham published the list "Next Generation Genomics: World Map of High-throughput Sequencers" about the new generation genome sequencing infrastructure providers. The genome sequencing laboratory of KPS Molecular Diagnostics has been chosen as one of the key genomic providers in the Central-European More»
Our genome sequencing lab is a part of the national r&d infrastructure network
Our genome sequencing laboratory and our Roche FLX Genome Sequencer FLX System was certified as a strategic research infrastructure by the National R&D Infrastructure Survey in this month. The Hungarian National R&D Infrastructure Survey launched as an alliance associate of the ESFRI (European Strategy Forum on Research Infrastructure) of the European Union. ESFRI, the European Strategy Forum on Research Infrastructures, is a strategic instrument More»
Our publication has been released in Nature Reviews Drug Discovery
In July, Nature Reviews Drug Discovery will publish our CEO's paper about the chances of development of novel drug compounds and targeted therapy in the future. In the 1990s, the breast cancer drug trastuzumab (Herceptin; Genentech/Roche) — an antibody specific for human epidermal growth factor receptor 2 (HER2; also known as ERBB2) — was approved based on trials in which HER2 expression levels were used to select patients in clinical trials. This provided More»
The benefit of science TODAY
The emergence of molecular-targeted medicine at the turn of the 21st century brought a breakthrough in the personalized treatment of tumors and inflammations, comparable only to the discovery of penicillin. At the turn of the nineteenth century infectious diseases were treated with “poisons” like Mercury in order to block multiplication of hostile cells, until technology has allowed specific targeting of bacteria with practically no interference with More»
Clinical course of laryngo-respiratory symptoms in gastro-oesophageal reflux disease during routine
BACKGROUND: Gastro-oesophageal reflux disease (GERD) can be associated with laryngo-respiratory symptoms (LRS) such as chronic cough, asthma or laryngeal symptoms. AIM: To analyse the long-term clinical course of LRS in a large population with GERD and LRS. Methods ProGERD is a prospective multicentre cohort study of 6215 adult out-patients with GERD. At baseline, the prevalence of LRS was assessed. Initial standardized treatment was esomeprazole for up to 8 weeks. More»
Exposure to Low-Dose Ionizing Radiation from Medical Imaging Procedures
Background: The growing use of imaging procedures in the United States has raised concerns about exposure to low-dose ionizing radiation in the general population. Methods: We identified 952,420 nonelderly adults (between 18 and 64 years of age) in five health care markets across the United States between January 1, 2005, and December 31, 2007. Utilization data were used to estimate cumulative effective doses of radiation from imaging procedures and to calculate population-based More»
Use and impact of early endoscopy in elderly patients with peptic ulcer hemorrhage: a population-bas
Background: Upper endoscopy performed within 1 day of presentation, or early endoscopy, has been proposed as an intervention to improve the efficiency and outcomes of care for patients with peptic ulcer hemorrhage. However, the use and outcomes have not been studied in a national, U.S.-based sample. Objective: To determine the prevalence and associated outcomes of early versus delayed endoscopy in bleeding peptic ulcers. Design: Using a 5% random More»
Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
Chronic infection with hepatitis C virus (HCV) affects 170 million people worldwide and is the leading cause of cirrhosis in North America. Although the recommended treatment for chronic infection involves a 48-week course of peginterferon--2b (PegIFN--2b) or --2a (PegIFN--2a) combined with ribavirin (RBV), it is well known that many patients will not be cured by treatment, and that patients of European ancestry have a significantly higher probability of being cured More»
Meta-analysis: Can Helicobacter pylori Eradication Treatment Reduce the Risk for Gastric Cancer?
Background: Helicobacter pylori infection is associated with gastric cancer, but the effect of eradication treatment on gastric cancer risk is not well defined. Purpose: To determine whether H. pylori eradication treatment can reduce the risk for gastric cancer. Data Sources: PubMed, EMBASE, Cochrane Library, Google Scholar, and online clinical trial registers through 31 January 2009, without language restrictions. Study Selection: Randomized trials that More»
Detecting malignant lesions by endoscopy in 2741 primary care dyspeptic patients w/o alarm symptoms
BACKGROUND & AIMS: Current guidelines recommend empirical, noninvasive approaches to manage dyspeptic patients without alarm symptoms, but concerns about missed lesions persist; the cost savings afforded by noninvasive approaches must be weighed against treatment delays. We investigated the prevalence of malignancies and other serious abnormalities in patients with dyspepsia and the cost of detecting these by endoscopy. METHODS: We studied 2741 primary-care More»
FDA Issues Early Communication about Ongoing Safety Review of Weight Loss Drug Orlistat
The U.S. Food and Drug Administration announced today that it is reviewing adverse event reports of liver injury in patients taking the weight loss drug orlistat, marketed as the prescription drug Xenical and the over-the-counter medication Alli. Between 1999 and 2008, the FDA received 32 reports of serious liver injury in patients taking orlistat. Of those cases, 27 reported hospitalization and six resulted in liver failure. Thirty of the adverse events occurred outside More»
Impact of Obesity on Bowel Preparation for Colonoscopy
Background & Aims: An inadequately cleansed colon can lead to missed lesions, repeat procedures, increased cost, and complications from colonoscopy. Because obesity, with its known link to colorectal neoplasia, might be associated with inadequate bowel cleansing, we investigated the impact of increased body mass index (BMI) on quality of bowel preparation at colonoscopy. Methods: All colonoscopy procedures performed at a tertiary referral center More»
Alcohol consumption, cigarette smoking, and the risk of recurrent acute and chronic pancreatitis.
BACKGROUND: Recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) are associated with alcohol consumption and cigarette smoking. The etiology of RAP and CP is complex, and effects of alcohol and smoking may be limited to specific patient subsets. We examined the current prevalence of alcohol use and smoking and their association with RAP and CP in patients evaluated at US referral centers. METHODS: The North American Pancreatitis Study 2, a multicenter consortium More»
Epigenomics AG: First Blood Test for Colorectal Cancer Available in Germany
First diagnostic laboratories start offering testing based on Epigenomics’ Septin9 biomarker on October 1st Test is able to detect colorectal cancer in a simple blood draw Press Release, Berlin, Germany and Seattle, WA, U.S.A., September 21, 2009 - Epigenomics AG (Frankfurt Prime Standard: ECX), a molecular diagnostics company focusing on the development and commercialization of in vitro diagnostic products for cancer, today announced that several German More»
Colorectal anatomy in adults at computed tomography colonography: normal distribution and the effect
BACKGROUND AND STUDY AIMS: Computed tomography colonography (CTC) is an accurate tool for assessing the large intestinal anatomy. Our aims were to determine the normal distribution of in vivo colorectal anatomy and to investigate the effect of age, sex, and body mass index (BMI) on colorectal length. PATIENTS AND METHODS: Asymptomatic adults who underwent primary CTC examination at a single institution over an 8-month period were evaluated. The interactive three-dimensional More»
Aspirin Use and Survival After Diagnosis of Colorectal Cancer
Aspirin reduces risk of colorectal neoplasia in randomized trials and inhibits tumor growth and metastases in animal models. However, the influence of aspirin on survival after diagnosis of colorectal cancer is unknown. Objective: To examine the association between aspirin use after colorectal cancer diagnosis on colorectal cancer–specific and overall survival. Design, Setting, and Participants: Prospective cohort study of 1279 men and women diagnosed More»
Proton-Pump Inhibitor Therapy Induces Acid-Related Symptoms in Healthy Volunteers After Withdrawal o
Background & Aims: Rebound acid hypersecretion (RAHS) has been demonstrated after 8 weeks of treatment with a proton-pump inhibitor (PPI). If RAHS induces acid-related symptoms, this might lead to PPI dependency and thus have important implications. Methods: A randomized, double-blind, placebo-controlled trial with 120 healthy volunteers was conducted. Participants were randomized to 12 weeks of placebo or 8 weeks of esomeprazole 40 mg/d followed More»
A Randomized Controlled Trial of Antioxidant Supplementation for Pain Relief in Patients With Chroni
Background & Aims: Oxidative stress has been implicated in the pathophysiology of chronic pancreatitis (CP). We evaluated the effects of antioxidant supplementation on pain relief, oxidative stress, and antioxidant status in patients with CP. Methods: In a placebo-controlled double blind trial, consecutive patients with CP were randomized to groups that were given placebo or antioxidants for 6 months. The primary outcome measure was pain relief, More»
Linoleic Acid, a Dietary N-6 Polyunsaturated Fatty Acid, and the Aetiology of Ulcerative Colitis
Objective: Dietary linoleic acid, an n-6 polyunsaturated fatty acid, is metabolised to arachidonic acid, a component of colonocyte membranes. Metabolites of arachidonic acid have pro-inflammatory properties and are increased in the mucosa of patients with ulcerative colitis. The aim of this investigation was to conduct the first prospective cohort study investigating if a high dietary intake of linoleic acid increases the risk of developing incident ulcerative colitis. Design More»
How Much Evidence Do We Need to Change Practices in Which We Firmly Believe?
Enough already! Randomized trials show that tight glucose control in patients with long-standing type 2 diabetes isn't beneficial. Should the glycosylated hemoglobin (HbA1c) level goal in patients with long-standing type 2 diabetes be 7%? 6.5%? Lower? Although many clinicians believe in tight control for patients with type 2 diabetes, recent studies suggest that this practice is not beneficial. Several recently published commentaries cite evidence that challenges More»
FDA: Cancer Warnings Required for TNF Blockers
The U.S. Food and Drug Administration is requiring stronger warnings in the prescribing information for a class of drugs known as TNF blockers. The warnings, which include an updated boxed warning, highlight the increased risk of cancer in children and adolescents who receive these drugs to treat juvenile rheumatoid arthritis, the inflammatory bowel disorder, Crohn’s disease, and other inflammatory diseases. In addition, the FDA is working with manufacturers More»
Famotidine for the prevention of peptic ulcers and oesophagitis in patients taking low-dose aspirin
Background: There are few therapeutic options for the prevention of gastrointestinal mucosal damage caused by low-dose aspirin. We therefore investigated the efficacy of famotidine, a well-tolerated histamine H2-receptor antagonist, in the prevention of peptic ulcers and erosive oesophagitis in patients receiving low-dose aspirin for vascular protection. Methods: Adult patients (aged ≥18 years) from the cardiovascular, cerebrovascular, More»
Primary Care Validation of a Single-Question Alcohol Screening Test
BACKGROUND: Unhealthy alcohol use is prevalent but under-diagnosed in primary care settings. OBJECTIVE: To validate, in primary care, a single-item screening test for unhealthy alcohol use recommended by the National Institute on Alcohol Abuse and Alcoholism (NIAAA). DESIGN: Cross-sectional study. PARTICIPANTS: Adult English-speaking patients recruited from primary care waiting rooms. MEASUREMENTS: Participants were asked the single screening question, More»
Upper Gastrointestinal Symptoms and Associated Disorders in Morbidly Obese Patients: A Prospective S
Objective To prospectively evaluate the frequency of upper gastrointestinal symptoms and associated disorders in morbidly obese patients with endoscopy and histology prior to their gastric bypass surgery in comparison with age- and sex-matched nonobese control subjects. Methods All patients who were scheduled to undergo laparoscopic gastric bypass for treatment of morbid obesity (body mass index, BMI > 40 kg/m2) during a 1-year period (n = 101) were included in More»
Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
Caloric restriction (CR), without malnutrition, delays aging and extends life span in diverse species; however, its effect on resistance to illness and mortality in primates has not been clearly established. We report findings of a 20-year longitudinal adult-onset CR study in rhesus monkeys aimed at filling this critical gap in aging research. In a population of rhesus macaques maintained at the Wisconsin National Primate Research Center, moderate CR lowered the incidence More»
Cancer Risk from Inflammatory Bowel Disease
Incidence of colorectal cancer did not change over time, although risk for CRC-related mortality declined. Background & Aims: Inflammatory bowel disease (IBD) is a risk factor for colorectal cancer (CRC). There have been marked changes in the management and treatment of IBD over the past decades, but little is known about how these changes have impacted morbidity and mortality (time trends in risk) of CRC in patients with More»
Adverse Events After Outpatient Colonoscopy in the Medicare Population
Background: Although use of colonoscopy has increased substantially among elderly Medicare beneficiaries, no one has described colonoscopy-related adverse events in a representative sample of Medicare patients. Objective: To determine risk for adverse events after outpatient colonoscopy in elderly patients. Design: Population-based, matched cohort study. Setting: Surveillance, Epidemiology, and End Results cancer registry areas. Patients: Random More»
Capsule Endoscopy versus Colonoscopy for the Detection of Polyps and Cancer
Background: An ingestible capsule consisting of an endoscope equipped with a video camera at both ends was designed to explore the colon. This study compared capsule endoscopy with optical colonoscopy for the detection of colorectal polyps and cancer. Methods: We performed a prospective, multicenter study comparing capsule endoscopy with optical colonoscopy (the standard for comparison) in a cohort of patients with known or suspected colonic disease for the detection More»
Hyperglycemia Can Increase Risk for Gastric Cancer
BACKGROUND & AIMS Although diabetes mellitus and hyperglycemia are considered to be possible risk factors for various types of malignancy, the epidemiologic evidence concerning gastric cancer is scarce. The aim of this study was to evaluate the impact of hemoglobin A1c (HbA1c) levels on gastric cancer occurrence and their interaction with Helicobacter pylori infection. METHODS A total of 2603 Japanese subjects aged>or=40 years were stratified More»
US Senate Passes Strict Bill on Smoking Prevention
Barack Obama signs strict act empowering the FDA to control tobacco production and marketing. The Family Smoking Prevention and Tobacco Control Act was designed "to protect the public health by providing the Food and Drug Administration with certain authority to regulate tobacco products, to amend title 5, United States Code, to make certain modifications in the Thrift Savings Plan, the Civil Service Retirement System, and the Federal Employees' Retirement More»
Computed Tomographic Colonography for Patients at High Risk of Colorectal Cancer
With nearly 150 000 cases detected annually, colorectal cancer is the second most common cause of cancer-related death in the United States.1 Over the past 2 decades, however, the annual death rate from colorectal cancer has been declining. This improvement has partially been attributed to an increase in colorectal cancer screening and surveillance nationally. Removal of polyps that have the potential for future malignant transformation and the detection of colorectal More»
Acid-Suppressive Medication Use and the Risk for Hospital-Acquired Pneumonia
Context The use of acid-suppressive medication has been steadily increasing, particularly in the inpatient setting, despite lack of an accepted indication in the majority of these patients. Objective To examine the association between acid-suppressive medication and hospital-acquired pneumonia. Design, Setting, and Patients Prospective pharmacoepidemiologic cohort study. All patients who were admitted to a large, urban, academic More»
The Safety of Metoclopramide Use in the First Trimester of Pregnancy
Background In various countries, metoclopramide is the antiemetic drug of choice in pregnant women, but insufficient information exists regarding its safety in pregnancy. Methods We investigated the safety of metoclopramide use during the first trimester of pregnancy by linking a computerized database of medications dispensed between January 1, 1998, and March 31, 2007, to all women registered in the Clalit Health Services, southern district of Israel, More»
Colorectal cancer incidence in the United States, 1999-2004
BACKGROUND By using recent national cancer surveillance data, the authors investigated colorectal cancer (CRC) incidence by subpopulation to inform the discussion of demographic-based CRC guidelines. METHODS Data included CRC incidence (1999-2004) from the combined National Program of Cancer Registries and Surveillance, Epidemiology, and End Results Program databases. Incidence rates (age-specific and age-adjusted to the 2000 US standard population) More»
Putting an End to Yo-Yo Dieting
A simple program of weigh-ins and supportive phone calls was as effective as a more elaborate approach. Losing weight is hard, but keeping it off is harder — most successful dieters regain some or all lost weight within a few years. To pinpoint the best approach to weight-loss maintenance, New Zealand researchers recruited 200 overweight women (age range, 25–70) who had lost at least 5% of their body weight within the previous 6 months. The More»
Timing and Tempo of First-Year Rapid Growth in Relation to Cardiovascular and Metabolic Risk Profile
Growth during infancy appears to be an important determinant of cardiovascular disease and type 2 diabetes later in life. Objectives To specify which period in the first year of life is related to determinants of cardiovascular disease and type 2 diabetes in early adulthood and to investigate the association between tempo of first-year weight gain (>0.67 SDs) and these determinants. Design, Setting, and Participants: Observational study using More»
Combination Hormone Therapy Linked to Increased Risk for Lung Cancer Mortality
Patients may ask about a widely reported study showing a link between hormone therapy (HT) and lung cancer mortality. The findings were reported Saturday at the American Society of Clinical Oncology's annual meeting. The analysis, performed among some 16,600 Women's Health Initiative participants, found that women taking estrogen-progestin faced increased risk for death from non–small-cell lung cancer, compared with placebo recipients. (Lung More»
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